أدريسين

جين من أنواع جينات الإنسان العاقل

☰ جدول المحتويات

نبذة تمهيدية
الوظيفة
الأهمية السريرية
المراجع
قراءة متعمقة

الأدريسين^[1]‏ (Mucosal vascular addressin cell adhesion molecule 1) هوَ بروتين يُشَفر بواسطة جين Addressin في الإنسان.^[2]^[3]^[4]^[5]

MADCAM1

التراكيب المتوفرة

بنك بيانات البروتين

Human UniProt search: PDBe RCSB

قائمة رموز معرفات بنك بيانات البروتين
1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9

المعرفات

الأسماء المستعارة

MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1

معرفات خارجية

الوراثة المندلية البشرية عبر الإنترنت 102670 GeneCards: 8174

علم الوجود الجيني
الوظيفة الجزيئية	• integrin binding involved in cell-matrix adhesion
المكونات الخلوية	• مكون تكاملي للغشاء • غشاء خلوي • غشاء
العمليات الحيوية	• leukocyte tethering or rolling • heterotypic cell-cell adhesion • التصاق الخلايا • cell-matrix adhesion • extracellular matrix organization • receptor clustering • استجابة مناعة • توصيل الإشارة • regulation of immune response • positive regulation of leukocyte migration • integrin-mediated signaling pathway • positive regulation of lymphocyte migration
المصادر:Amigo / QuickGO

أورثولوج

الأنواع

الإنسان

الفأر

n/a

n/a


Q13477


n/a

RefSeq (مرسال ر.ن.ا.)


‏NM_130760 NM_130762، ‏NM_130760


n/a

RefSeq (بروتين)


‏NP_570118 NP_570116، ‏NP_570118


n/a

الموقع (UCSC

n/a

بحث ببمد

[1]

n/a

ويكي بيانات

الوظيفة

الأهمية السريرية

المراجع

"Al-Qamoos القاموس - English Arabic dictionary / قاموس إنجليزي عربي". www.alqamoos.org. مؤرشف من الأصل في 24 فبراير 201924 فبراير 2019.
Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097.
"Entrez Gene: mucosal vascular addressin cell adhesion molecule 1". مؤرشف من الأصل في 05 ديسمبر 2010.
Addressin at إي ميديسين Dictionary نسخة محفوظة 01 ديسمبر 2016 على موقع واي باك مشين.
Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (أبريل 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404.

قراءة متعمقة

Ohara H, Isomoto H, Wen CY, et al. (2003). "Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis". World J. Gastroenterol. 9 (12): 2701–5. PMID 14669317.
Ikeda S, Kudsk KA, Fukatsu K, et al. (2003). "Enteral feeding preserves mucosal immunity despite in vivo MAdCAM-1 blockade of lymphocyte homing". Ann. Surg. 237 (5): 677–85, discussion 685. doi:10.1097/01.SLA.0000064364.40406.EA. PMC . PMID 12724634.
Tan K, Casasnovas JM, Liu JH, et al. (1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832.
de Château M, Chen S, Salas A, Springer TA (2001). "Kinetic and mechanical basis of rolling through an integrin and novel Ca2+-dependent rolling and Mg2+-dependent firm adhesion modalities for the alpha 4 beta 7-MAdCAM-1 interaction". Biochemistry. 40 (46): 13972–9. doi:10.1021/bi011582f. PMID 11705388.
Miles A, Liaskou E, Eksteen B, et al. (2008). "CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow". Am. J. Physiol. Gastrointest. Liver Physiol. 294 (5): G1257–67. doi:10.1152/ajpgi.00266.2007. PMID 18308860.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC . PMID 16344560.
Grayson MH, Hotchkiss RS, Karl IE, et al. (2003). "Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node". Am. J. Physiol. Heart Circ. Physiol. 284 (6): H2213–26. doi:10.1152/ajpheart.00999.2002. PMID 12586641.
Fujisaki S, Tomita R, Park YJ, et al. (2004). "Semiquantative analysis of expression of mucosal addressin cell adhesion molecule-1 during small bowel graft rejection in rats". Transplant. Proc. 36 (2): 348–9. doi:10.1016/j.transproceed.2003.12.010. PMID 15050155.
Nishimura T (2003). "Expression of potential lymphocyte trafficking mediator molecules in the mammary gland". Vet. Res. 34 (1): 3–10. doi:10.1051/vetres:2002045. PMID 12588680.
Ogawa H, Binion DG, Heidemann J, et al. (2005). "Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells". Am. J. Physiol., Cell Physiol. 288 (2): C272–81. doi:10.1152/ajpcell.00406.2003. PMID 15483224.
Ruiz-Velasco N; Guerrero-Esteo M; Briskin MJ; Teixidó J (2000). "The alpha(4) integrin subunit Tyr(187) has a key role in alpha(4)beta(7)-dependent cell adhesion". J. Biol. Chem. 275 (10): 7052–9. doi:10.1074/jbc.275.10.7052. PMID 10702270.
Di Sabatino A, Rovedatti L, Rosado MM, et al. (2009). "Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood". Hum. Pathol. 40 (5): 699–704. doi:10.1016/j.humpath.2008.10.014. PMID 19157500.
Bowlus CL, Karlsen TH, Broomé U, et al. (2006). "Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis". J. Hepatol. 45 (5): 704–10. doi:10.1016/j.jhep.2006.03.012. PMID 16750586.
Ambruzova Z, Mrazek F, Raida L, et al. (2009). "Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation". Hum. Immunol. 70 (6): 457–60. doi:10.1016/j.humimm.2009.03.008. PMID 19286444.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Arihiro S, Ohtani H, Suzuki M, et al. (2002). "Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease". Pathol. Int. 52 (5–6): 367–74. doi:10.1046/j.1440-1827.2002.01365.x. PMID 12100519.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC . PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Shroff HN, Schwender CF, Baxter AD, et al. (1998). "Novel modified tripeptide inhibitors of alpha 4 beta 7 mediated lymphoid cell adhesion to MAdCAM-1". Bioorg. Med. Chem. Lett. 8 (13): 1601–6. doi:10.1016/S0960-894X(98)00286-8. PMID 9873398.
Dando J, Wilkinson KW, Ortlepp S, et al. (2002). "A reassessment of the MAdCAM-1 structure and its role in integrin recognition". Acta Crystallogr. D. 58 (Pt 2): 233–41. doi:10.1107/S0907444901020522. PMID 11807247.