وحيدة بيتا لهرمونات البروتين السكري (TSHB) أو هرمون تنشيط الغدة الدرقية، بيتا (Thyroid stimulating hormone, beta) المعروف أيضا باسم TSHB، هو بروتين في البشر مُشفّر بالجين TSHB [1][2].
| TSHB | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| المعرفات | |||||||||||||||||
| الأسماء المستعارة | TSHB, TSH-B, TSH-BETA, thyroid stimulating hormone beta, Thyroid stimulating hormone, beta, thyroid stimulating hormone subunit beta | ||||||||||||||||
| معرفات خارجية | الوراثة المندلية البشرية عبر الإنترنت 188540 MGI: MGI:98848 HomoloGene: 463 GeneCards: 7252 | ||||||||||||||||
| |||||||||||||||||
| أورثولوج | |||||||||||||||||
| الأنواع | الإنسان | الفأر | |||||||||||||||
| أنتريه | 7252 | 22094 | |||||||||||||||
| Ensembl | ENSG00000134200 | ENSMUSG00000027857 | |||||||||||||||
| يونيبروت | |||||||||||||||||
| RefSeq (مرسال ر.ن.ا.) | |||||||||||||||||
| RefSeq (بروتين) | |||||||||||||||||
| الموقع (UCSC | n/a | Chr 3: 102.78 – 102.78 Mb | |||||||||||||||
| بحث ببمد | [1] | [2] | |||||||||||||||
| ويكي بيانات | |||||||||||||||||
الوظيفة
هرمون منبه الدرقية (TSH) هو بروتين سكري مغاير (heterodimer) يتصل برابِطٌ غيرتَساهُمِيّ، وهو جزء من عائلة هرمونات الغدة النخامية التي تحتوي على وحيدة ألفا مشتركة (TSHA) ووحيدة بيتا فريدة (هذا البروتين) وهي التي تضفي النَوْعِيَّة (أو الخصوصية) [3].
مقالات ذات صلة
للإستزادة
- Bonomi M, Proverbio MC, Weber G, et al. (2001). "Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene". J. Clin. Endocrinol. Metab. 86 (4): 1600–4. doi:10.1210/jc.86.4.1600. PMID 11297590.
- Vuissoz JM, Deladoëy J, Buyukgebiz A, et al. (2001). "New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism". J. Clin. Endocrinol. Metab. 86 (9): 4468–71. doi:10.1210/jc.86.9.4468. PMID 11549695.
- Karges B, LeHeup B, Schoenle E, et al. (2004). "Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe". Horm. Res. 62 (3): 149–55. doi:10.1159/000080071. PMID 15297803.
- Kabadi UM, Premachandra BN (2007). "Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?". Endocr Pract. 13 (6): 615–9. doi:10.4158/ep.13.6.615. PMID 17954417.
- Miyai S, Yoshimura S, Iwasaki Y, et al. (2005). "Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line". Cell Tissue Res. 322 (2): 269–77. doi:10.1007/s00441-005-0033-z. PMID 16133148.
- Pierce JG (1971). "Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones". Endocrinology. 89 (6): 1331–44. doi:10.1210/endo-89-6-1331. PMID 5002675.
- Atzmon G, Barzilai N, Surks MI, Gabriely I (2009). "Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity". J. Clin. Endocrinol. Metab. 94 (12): 4768–75. doi:10.1210/jc.2009-0808. PMC . PMID 19837933.
- Landa I, Ruiz-Llorente S, Montero-Conde C, et al. (2009). Gibson G (المحرر). "The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors". PLoS Genet. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC . PMID 19730683.
- Pohlenz J, Dumitrescu A, Aumann U, et al. (2002). "Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene". J. Clin. Endocrinol. Metab. 87 (1): 336–9. doi:10.1210/jc.87.1.336. PMID 11788671.
- Miyoshi I, Kasai N, Hayashizaki Y (1994). "[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]". Nippon Rinsho. 52 (4): 940–7. PMID 8196184.
- Borck G, Topaloglu AK, Korsch E, et al. (2004). "Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect". J. Clin. Endocrinol. Metab. 89 (8): 4136–41. doi:10.1210/jc.2004-0494. PMID 15292359.
- Comings DE, Gade-Andavolu R, Gonzalez N, et al. (2000). "A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory". Clin. Genet. 58 (5): 375–85. doi:10.1034/j.1399-0004.2000.580508.x. PMID 11140838.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC . PMID 15489334.
- Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302.
- Loinder K, Söderström M (2005). "An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene". J. Steroid Biochem. Mol. Biol. 97 (4): 322–7. doi:10.1016/j.jsbmb.2005.06.031. PMID 16216492.
- Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID 18240029.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC . PMID 12477932.
- Brumm H, Pfeufer A, Biebermann H, et al. (2002). "Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect". J. Clin. Endocrinol. Metab. 87 (10): 4811–6. doi:10.1210/jc.2002-020297. PMID 12364478.
- Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). "Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death". Eur. J. Endocrinol. 160 (6): 985–91. doi:10.1530/EJE-08-0953. PMID 19273570.
- Schaefer JS, Klein JR (2009). "A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid". Gen. Comp. Endocrinol. 162 (3): 241–4. doi:10.1016/j.ygcen.2009.04.006. PMC . PMID 19364510.
مراجع
- Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (September 1988). "Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species". J. Biol. Chem. 263 (25): 12538–42. PMID 2457586. مؤرشف من الأصل في 25 أبريل 2020.
- Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (December 1988). "The structure of the human thyrotropin beta-subunit gene". Gene. 73 (2): 489–97. doi:10.1016/0378-1119(88)90513-6. PMID 3243440.
- "Entrez Gene: TSHB". مؤرشف من الأصل في 12 أبريل 2010.