بريفيكان

جين من أنواع جينات الإنسان العاقل

☰ جدول المحتويات

نبذة تمهيدية
الوظيفة
الأهمية السريرية
المراجع
قراءة متعمقة

بريفيكان‏ (Brevican) هوَ بروتين يُشَفر بواسطة جين بريفيكان في الإنسان.^[1]^[2]^[3]^[4]^[5]

BCAN

المعرفات

الأسماء المستعارة

BCAN, BEHAB, CSPG7, Brevican

معرفات خارجية

الوراثة المندلية البشرية عبر الإنترنت 600347 MGI: MGI:1096385 HomoloGene: 7244 GeneCards: 63827

علم الوجود الجيني
الوظيفة الجزيئية	• hyaluronic acid binding • carbohydrate binding • extracellular matrix structural constituent
المكونات الخلوية	• غشاء • منطقة خارج الخلية • lysosomal lumen • تجويف غولجي • anchored component of membrane • نسيج خارج الخلية • glutamatergic synapse
العمليات الحيوية	• skeletal system development • chondroitin sulfate biosynthetic process • extracellular matrix organization • central nervous system development • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • hippocampus development • التصاق الخلايا • synapse maturation
المصادر:Amigo / QuickGO

نمط التعبير عن الحمض النووي الريبوزي

المزيد من بيانات التعبير المرجعية

أورثولوج

الأنواع

الإنسان

الفأر


Q96GW7


Q61361

RefSeq (مرسال ر.ن.ا.)


‏NM_021948، ‏NM_198427، ‏XM_017002047 XM_011509866، ‏NM_021948، ‏NM_198427، ‏XM_017002047


‏NM_007529، ‏XM_006500936، ‏XM_006500937، ‏XM_030252396 NM_001109758، ‏NM_007529، ‏XM_006500936، ‏XM_006500937، ‏XM_030252396

RefSeq (بروتين)


‏NP_940819، ‏XP_011508168، ‏XP_016857536 NP_068767، ‏NP_940819، ‏XP_011508168، ‏XP_016857536


‏NP_031555، ‏XP_006500999، ‏XP_006501000، ‏XP_030108256 NP_001103228، ‏NP_031555، ‏XP_006500999، ‏XP_006501000، ‏XP_030108256

الموقع (UCSC

n/a

Chr 3: 87.99 – 88 Mb

بحث ببمد

[1]

[2]

ويكي بيانات

الوظيفة

الأهمية السريرية

المراجع

Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.
"Entrez Gene: BCAN brevican". مؤرشف من الأصل في 05 ديسمبر 2010.
Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.

قراءة متعمقة

Hu B, Kong LL, Matthews RT, Viapiano MS (Sep 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry. 283 (36): 24848–59. doi:10.1074/jbc.M801433200. PMC . PMID 18611854.
Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED (Nov 1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry. 270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID 7592978.
Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10116–21. doi:10.1073/pnas.94.19.10116. PMC . PMID 9294172.
Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC . PMID 12975309.
Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L (Sep 2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research. 63 (18): 5685–90. PMID 14522884.
Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T (Sep 2003). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences. 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776.
Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications. 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT (Aug 2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research. 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.