عامل النمو المحول بيتا 2

جين من أنواع جينات الإنسان العاقل

عامل النمو المحول بيتا 2 (TGF-β2) هو من البروتينات التي تدعى السيتوكين التي تقوم بوظائف خلوية عديدة ولها دور حيوي في التخلق الجنيني، كما إنه بروتين مرتبط بالغليكوزيل خارج خلوي.^[1]^[2]^[3] كذلك يعرف عن تأثيره المثبط لأورام الخلايا التائية المعتمد على الإنترلوكين.

Transforming growth factor, beta 2

بنك بيانات البروتينات rendering based on 1tfg.

التراكيب المتوفرة

بنك بيانات البروتين

بحث أورثولوغ: PDBe, RCSB

قائمة رموز معرفات بنك بيانات البروتين
1TFG, 2TGI, 4KXZ

المعرفات

الرمز، (أو الرموز)

TGFB2; LDS4; TGF-beta2

معرفات خارجية

OMIM: 190220 MGI: 98726 هومولوجين: 2432 بطاقات الجينات: TGFB2 Gene

علم الوجود الجيني
الوظيفة الجزيئية	• beta-amyloid binding • receptor signaling protein serine/threonine kinase activity • receptor binding • type II transforming growth factor beta receptor binding • cytokine activity • transforming growth factor beta receptor binding • protein binding • growth factor activity • type III transforming growth factor beta receptor binding • protein homodimerization activity • protein heterodimerization activity
المكونات الخلوية	• extracellular region • extracellular space • endosome • axon • extracellular matrix • platelet alpha granule lumen • neuronal cell body
العملية الإحيائية	• cell morphogenesis • cartilage condensation • angiogenesis • eye development • response to hypoxia • epithelial to mesenchymal transition • hair follicle development • blood vessel remodeling • platelet degranulation • heart morphogenesis • heart valve morphogenesis • protein phosphorylation • cell cycle arrest • transforming growth factor beta receptor signaling pathway • SMAD protein import into nucleus • cell-cell signaling • axon guidance • salivary gland morphogenesis • heart development • blood coagulation • cell death • cell proliferation • positive regulation of cell proliferation • negative regulation of cell proliferation • glial cell migration • response to wounding • embryo development • cardioblast differentiation • positive regulation of gene expression • positive regulation of epithelial cell migration • negative regulation of alkaline phosphatase activity • positive regulation of epithelial to mesenchymal transition • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of macrophage cytokine production • positive regulation of phosphatidylinositol 3-kinase signaling • cell growth • cell migration • signal transduction by protein phosphorylation • hemopoiesis • platelet activation • extracellular matrix organization • collagen fibril organization • positive regulation of cell growth • negative regulation of cell growth • neutrophil chemotaxis • hair follicle morphogenesis • activation of protein kinase activity • response to progesterone • positive regulation of stress-activated MAPK cascade • regulation of transforming growth factor beta2 production • positive regulation of cell adhesion mediated by integrin • wound healing • dopamine biosynthetic process • odontogenesis • response to drug • catagen • uterine wall breakdown • positive regulation of neuron apoptotic process • cell-cell junction organization • positive regulation of integrin biosynthetic process • positive regulation of ossification • positive regulation of cell cycle • positive regulation of heart contraction • somatic stem cell division • cell development • embryonic digestive tract development • neuron fate commitment • neuron development • generation of neurons • negative regulation of epithelial cell proliferation • positive regulation of protein secretion • negative regulation of immune response • positive regulation of immune response • positive regulation of cell division • positive regulation of catagen • positive regulation of cardioblast differentiation • cardiac muscle cell proliferation • cardiac epithelial to mesenchymal transition • face morphogenesis • pathway-restricted SMAD protein phosphorylation • SMAD protein signal transduction • negative regulation of cartilage development • positive regulation of activation-induced cell death of T cells • extrinsic apoptotic signaling pathway • regulation of extracellular matrix organization • regulation of complement-dependent cytotoxicity • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
المصادر: Amigo / QuickGO