مستقبل ريتينويد أكس ألفا

جين في إنسان عاقل

☰ جدول المحتويات

نبذة تمهيدية
مخطط مسار تفاعلي
التفاعلات
طالع أيضا
المصادر

مستقبل ريتينويد أكس ألفا (Retinoid X receptor alpha)‏ (مختصره RXR-alpha), ويعرف كذلك مستقبل نووي عائلة 2، مجموعة ب، عضو 1 (nuclear receptor subfamily 2, group B, member 1)‏ (مختصره NR2B1) هو is a مستقبل نووي موجود عند الإنسان مشفر في المورثة RXRA.^[1]

Retinoid X receptor, alpha

بنك بيانات البروتينات rendering based on 1by4.

التراكيب المتوفرة

بنك بيانات البروتين

بحث أورثولوغ: PDBe, RCSB

قائمة رموز معرفات بنك بيانات البروتين
1BY4, 1DSZ, 1FBY, 1FM6, 1FM9, 1G1U, 1G5Y, 1K74, 1LBD, 1MV9, 1MVC, 1MZN, 1R0N, 1RDT, 1RXR, 1XLS, 1XV9, 1XVP, 1YNW, 2ACL, 2NLL, 2P1T, 2P1U, 2P1V, 2ZXZ, 2ZY0, 3DZU, 3DZY, 3E00, 3E94, 3FAL, 3FC6, 3FUG, 3H0A, 3KWY, 3NSP, 3NSQ, 3OAP, 3OZJ, 3PCU, 3R29, 3R2A, 3R5M, 3UVV, 4CN2, 4CN3, 4CN5, 4CN7, 4J5W, 4J5X, 4K4J, 4K6I, 4M8E, 4M8H, 4N5G, 4N8R, 4NQA, 4OC7, 4POH, 4POJ, 4PP3, 4PP5

المعرفات

الرمز، (أو الرموز)

RXRA; NR2B1

معرفات خارجية

OMIM: 180245 MGI: 98214 هومولوجين: 2220 الاتحاد الدولي للصيدلة الأساسية والسريرية: 610 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 2061 بطاقات الجينات: RXRA Gene

علم الوجود الجيني
الوظيفة الجزيئية	• RNA polymerase II regulatory region sequence-specific DNA binding • DNA binding • double-stranded DNA binding • transcription factor activity, sequence-specific DNA binding • steroid hormone receptor activity • retinoic acid receptor activity • transcription coactivator activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • 9-cis retinoic acid receptor activity • protein binding • zinc ion binding • enzyme binding • protein domain specific binding • chromatin DNA binding • protein complex binding • vitamin D receptor binding • retinoic acid receptor binding • sequence-specific DNA binding • transcription regulatory region DNA binding • retinoic acid-responsive element binding • protein heterodimerization activity • vitamin D response element binding
المكونات الخلوية	• nuclear chromatin • nucleus • nucleoplasm • axon • receptor complex • RNA polymerase II transcription factor complex
العملية الإحيائية	• negative regulation of transcription from RNA polymerase II promoter • in utero embryonic development • liver development • maternal placenta development • transcription initiation from RNA polymerase II promoter • vitamin metabolic process • inflammatory response • midgut development • embryo implantation • aging • cholesterol metabolic process • bile acid metabolic process • negative regulation of cell proliferation • response to selenium ion • gene expression • bile acid and bile salt transport • modulation by virus of host morphology or physiology • axon regeneration • regulation of myelination • response to retinoic acid • cellular response to insulin stimulus • response to vitamin A • response to vitamin D • peroxisome proliferator activated receptor signaling pathway • camera-type eye development • positive regulation of apoptotic process • steroid hormone mediated signaling pathway • cellular lipid metabolic process • small molecule metabolic process • response to ethanol • positive regulation of transcription from RNA polymerase II promoter • positive regulation of translational initiation by iron • retinoic acid receptor signaling pathway • protein homotetramerization • response to glucocorticoid • ventricular cardiac muscle tissue morphogenesis • ventricular cardiac muscle cell differentiation • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development • regulation of branching involved in prostate gland morphogenesis • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
المصادر: Amigo / QuickGO

نمط التعبير عن الحمض النووي الريبوزي

مصادر أخرى عن بيانات أنماط التعبير

التقويمات

الأنواع

الإنسان

الفأر

قاعدة بيانات مرجعية (مرسال ر.ن.ا)

NM_001291920

NM_001290481

قاعدة بيانات مرجعية (بروتين)

NP_001278849

NP_001277410

الموقع (قاعدة بيانات UCSC)

Chr 9:
134.32 – 134.44 Mb

Chr 2:
27.68 – 27.76 Mb

بحث ببمد

[1]

[2]

مخطط مسار تفاعلي

اضغط على المورثة أو البروتين أو المادة للذهاب إلى المقالة المتعلقة بها. ^{[§ 1]}

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مسار تكوين فيتامين د تعديل

يمكن تعديل مخطط مسار التكوين التفاعلي في WikiPathways: "VitaminDSynthesis_WP1531".

مستقبل ريتينويد أكس ألفا


المعرفات
الرمز	RXRA
Ensembl Transcript ID	ENST00000484822 ENST00000356384 ENST00000481739 ENST00000649020 ENST00000672570
Ensembl Gene ID	ENSG00000186350
أنتريه	6256
HUGO	10477
أوميم	180245
هومولوجين	2220
RefSeq	NM_002957
يونيبروت	P19793
بيانات أخرى
الموقع الكروموسومي	Chr. 9 q34

التفاعلات

أظهر مستقبل ريتنويد أكس ألفا تآثرات مع:

BCL3,^[2]
BRD8,^[3]
CLOCK,^[4]
FXR^[5]
IGFBP3,^[6]
ITGB3BP,^[7]
LXR-β,^[5]
MyoD,^[8]
NCOA6,^[9]^[10]^[11]^[12]
NFKBIB,^[13]
NPAS2,^[4]
NRIP1,^[14]^[15]
NR4A1,^[16]
NCOA2,^[17]
NCOA3,^[18]
POU2F1,^[19]^[20]
PPARGC1A,^[21]
مستقبل منشط لمكاثر البيروكسيسوم النوع-غاما,^[22]^[23]^[24]
RNF8,^[25]
مستقبل حمض الريتينويك ألفا,^[26]^[27]
SHP,^[28]^[29]
TADA3L,^[30]
TBP,^[31]
TRIM24,^[32]^[33]
TR-β,^[34]^[35]
مستقبل كالسيتريول.^[17]^[36]

طالع أيضا

مستقبل ريتنويد أكس

المصادر

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