عامل النمو المحول بيتا 1

عامل النمو المحول بيتا 1 (TGF-β1) هو بروتين يتبع عائلة عامل النمو المحول التابعة لمجموعة السيتوكين. يساهم هذه البروتين في عدد من الوظائف الخلوية مثل تكاثر ونمو الخلايا والتمايز الخلوي والااستماتة.^[1][2]

Transforming growth factor, beta 1
بنك بيانات البروتينات rendering based on 1kla.
التراكيب المتوفرة بنك بيانات البروتين بحث أورثولوغ: PDBe, RCSB قائمة رموز معرفات بنك بيانات البروتين 1KLA, 1KLC, 1KLD, 3KFD, 4KV5
المعرفات
الرمز، (أو الرموز)	TGFB1; CED; DPD1; LAP; TGFB; TGFbeta
معرفات خارجية	OMIM: 190180 MGI: 98725 هومولوجين: 540 مختبر علم الأحياء الجزيئي الأوروبي الكيميائي: 1795178 بطاقات الجينات: TGFB1 Gene
علم الوجود الجيني الوظيفة الجزيئية • glycoprotein binding • antigen binding • type II transforming growth factor beta receptor binding • cytokine activity • protein binding • growth factor activity • enzyme binding • type I transforming growth factor beta receptor binding • type III transforming growth factor beta receptor binding • protein homodimerization activity • protein heterodimerization activity • protein N-terminus binding المكونات الخلوية • extracellular region • proteinaceous extracellular matrix • extracellular space • nucleus • cytoplasm • Golgi lumen • plasma membrane • microvillus • cell surface • axon • platelet alpha granule lumen • neuronal cell body • blood microparticle العملية الإحيائية • protein import into nucleus, translocation • negative regulation of transcription from RNA polymerase II promoter • MAPK cascade • ureteric bud development • response to hypoxia • epithelial to mesenchymal transition • negative regulation of protein phosphorylation • positive regulation of protein phosphorylation • regulation of sodium ion transport • chondrocyte differentiation • hematopoietic progenitor cell differentiation • connective tissue replacement involved in inflammatory response wound healing • adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains • tolerance induction to self antigen • platelet degranulation • protein phosphorylation • protein export from nucleus • ATP biosynthetic process • phosphate-containing compound metabolic process • cellular calcium ion homeostasis • inflammatory response • cell cycle arrest • mitotic cell cycle checkpoint • epidermal growth factor receptor signaling pathway • transforming growth factor beta receptor signaling pathway • common-partner SMAD protein phosphorylation • SMAD protein complex assembly • SMAD protein import into nucleus • negative regulation of neuroblast proliferation • salivary gland morphogenesis • endoderm development • female pregnancy • aging • blood coagulation • negative regulation of DNA replication • positive regulation of cell proliferation • negative regulation of cell proliferation • germ cell migration • response to radiation • response to wounding • response to glucose • defense response to fungus, incompatible interaction • positive regulation of vascular endothelial growth factor production • positive regulation of gene expression • negative regulation of gene expression • negative regulation of extracellular matrix disassembly • positive regulation of epithelial to mesenchymal transition • macrophage derived foam cell differentiation • positive regulation of fibroblast migration • positive regulation of peptidyl-threonine phosphorylation • positive regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of macrophage cytokine production • oligodendrocyte development • cell growth • regulation of striated muscle tissue development • regulation of transforming growth factor beta receptor signaling pathway • modulation by virus of host morphology or physiology • evasion or tolerance of host defenses by virus • viral life cycle • negative regulation of cell-cell adhesion • platelet activation • extracellular matrix organization • hyaluronan catabolic process • negative regulation of ossification • negative regulation of cell growth • regulation of cell migration • positive regulation of cell migration • positive regulation of bone mineralization • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of histone deacetylation • organ regeneration • positive regulation of protein complex assembly • positive regulation of exit from mitosis • lipopolysaccharide-mediated signaling pathway • positive regulation of cellular protein metabolic process • response to estradiol • response to progesterone • regulation of interleukin-23 production • negative regulation of interleukin-17 production • positive regulation of interleukin-17 production • receptor catabolic process • positive regulation of superoxide anion generation • mononuclear cell proliferation • positive regulation of collagen biosynthetic process • positive regulation of peptidyl-serine phosphorylation • response to vitamin D • response to laminar fluid shear stress • positive regulation of histone acetylation • positive regulation of protein dephosphorylation • negative regulation of T cell proliferation • regulation of protein import into nucleus • positive regulation of protein import into nucleus • positive regulation of odontogenesis • response to drug • myelination • regulation of apoptotic process • myeloid dendritic cell differentiation • T cell homeostasis • positive regulation of apoptotic process • positive regulation of MAP kinase activity • protein kinase B signaling • positive regulation of blood vessel endothelial cell migration • negative regulation of blood vessel endothelial cell migration • positive regulation of phosphatidylinositol 3-kinase activity • ossification involved in bone remodeling • regulatory T cell differentiation • cell-cell junction organization • negative regulation of cell differentiation • negative regulation of fat cell differentiation • negative regulation of myoblast differentiation • negative regulation of cell cycle • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • active induction of host immune response by virus • positive regulation of isotype switching to IgA isotypes • cell development • lymph node development • digestive tract development • negative regulation of skeletal muscle tissue development • inner ear development • positive regulation of epithelial cell proliferation • negative regulation of epithelial cell proliferation • positive regulation of protein secretion • negative regulation of phagocytosis • positive regulation of chemotaxis • positive regulation of NF-kappaB transcription factor activity • regulation of binding • regulation of DNA binding • positive regulation of smooth muscle cell differentiation • negative regulation of release of sequestered calcium ion into cytosol • positive regulation of protein kinase B signaling • regulation of blood vessel remodeling • face morphogenesis • frontal suture morphogenesis • pathway-restricted SMAD protein phosphorylation • positive regulation of SMAD protein import into nucleus • SMAD protein signal transduction • mammary gland branching involved in thelarche • branch elongation involved in mammary gland duct branching • regulation of branching involved in mammary gland duct morphogenesis • negative regulation of gene silencing by miRNA • regulation of cartilage development • lens fiber cell differentiation • response to cholesterol • positive regulation of cell cycle arrest • cellular response to organic cyclic compound • cellular response to dexamethasone stimulus • cellular response to transforming growth factor beta stimulus • extracellular matrix assembly • positive regulation of branching involved in ureteric bud morphogenesis • extrinsic apoptotic signaling pathway • negative regulation of hyaluronan biosynthetic process • positive regulation of extracellular matrix assembly • positive regulation of NAD+ ADP-ribosyltransferase activity • regulation of actin cytoskeleton reorganization • positive regulation of transcription regulatory region DNA binding المصادر: Amigo / QuickGO
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مصادر أخرى عن بيانات أنماط التعبير
التقويمات
الأنواع	الإنسان	الفأر
أنتريه	7040	21803
انسمبل	ENSG00000105329	ENSMUSG00000002603
يونيبروت	P01137	P04202
قاعدة بيانات مرجعية (مرسال ر.ن.ا)	NM_000660	NM_011577
قاعدة بيانات مرجعية (بروتين)	NP_000651	NP_035707
الموقع (قاعدة بيانات UCSC)	Chr 19: 41.3 – 41.35 Mb	Chr 7: 25.69 – 25.71 Mb
بحث ببمد	[1]	[2]

مقالات ذات صلة

• عامل النمو المحول بيتا

مصادر

موسوعات ذات صلة :

• موسوعة الكيمياء الحيوية