أسرة ناقل المذاب

المذاب الناقل (SLC) وهي مجموعة من بروتينات النقل عبر الأغشية تشمل أكثر من 300 عضو في منظمة في 51 عائلة. وتقع معظم أعضاء مجموعة أو عائلة SLC في غشاء الخلية. واقترح تسميات SLC عن طريق لجنة التسمية HUGO Gene Nomenclature Committee HUGO وهو أساس لأسماء HGNC الرسمية للجينات تكود هذه الناقلين. ويمكن الاطلاع على تسمية أكثر عمومية من خلال قاعدة بيانات تصنيف الناقل TCDB.

قائمة الأنواع أو العوائل

(1) high-affinity glutamate and neutral amino acid transporter^[1]
- (SLC1A1, SLC1A2, SLC1A3, SLC1A4, SLC1A5, SLC1A6, SLC1A7)
(2) ناقل الغلوكوز^[2]
- (SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6, SLC2A7, SLC2A8, SLC2A9, SLC2A10, SLC2A11, SLC2A12, SLC2A13, SLC2A14)
(3) heavy subunits of heterodimeric amino acid transporters^[3]
- (SLC3A1, SLC3A2)
(4) bicarbonate transporter^[4]
- (SLC4A1, SLC4A2, SLC4A3, SLC4A4, SLC4A5, SLC4A6, SLC4A7, SLC4A8, SLC4A9, SLC4A10, SLC4A11)
(5) sodium glucose cotransporter^[5]
- (SLC5A1, ناقل مشارك صوديوم/جلوكوز 2, SLC5A3, SLC5A4, ناقل صوديوم-يود, SLC5A6, SLC5A7, SLC5A8, SLC5A9, SLC5A10, SLC5A11, SLC5A12)
(6) صوديوم- and كلوريد-dependent sodium:neurotransmitter symporters^[6]
- (SLC6A1, ناقل النورإبينفرين, ناقل الدوبامين, ناقل السيروتونين, SLC6A5, SLC6A6, SLC6A7, SLC6A8, SLC6A9, SLC6A10, SLC6A11, SLC6A12, SLC6A13, SLC6A14, SLC6A15, SLC6A16, SLC6A17, SLC6A18, SLC6A19, SLC6A20)
(7) cationic amino acid transporter/glycoprotein-associated^[7]
- cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4)
- glycoprotein-associated/light or catalytic subunits of heterodimeric amino acid transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A10, SLC7A11, SLC7A13, SLC7A14)
(8) مبادل كالسيوم-صوديوم^[8]
- (مبادل كالسيوم-صوديوم, SLC8A2, SLC8A3)
(9) Na+/H+ exchanger^[9]
- (SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9A8, SLC9A9, SLC9A10, SLC9A11, SLC9B1, SLC9B2)
(10) sodium bile salt cotransport^[10]
- (SLC10A1, SLC10A2, SLC10A3, SLC10A4, SLC10A5, SLC10A6, SLC10A7)
(11) proton coupled metal ion transporter^[11]
- (SLC11A1, SLC11A2)
(12) electroneutral cation-Cl cotransporter^[12]
- (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9)
(13) Na+-sulfate/carboxylate cotransporter^[13]
- (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5)
(14) urea transporter^[14]
- (SLC14A1, SLC14A2)
(15) proton oligopeptide cotransporter^[15]
- (SLC15A1, SLC15A2, SLC15A3, SLC15A4)
(16) monocarboxylate transporter^[16]
- (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14)
(17) vesicular glutamate transporter^[17]
- (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9)
(18) ناقل أحادي الأمين الحويصلي^[18]
- (ناقل أحادي الأمين الحويصلي 1, ناقل أحادي الأمين الحويصلي 2, SLC18A3)
(19) حمض الفوليك/thiamine transporter^[19]
- (SLC19A1, SLC19A2, SLC19A3)
(20) type III Na+-phosphate cotransporter^[20]
- (SLC20A1, SLC20A2)
(21) organic anion transporting^[21]
- subfamily 1 (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1)
- subfamily 2 (SLCO2A1, SLCO2B1)
- subfamily 3 (SLCO3A1)
- subfamily 4 (SLCO4A1, SLCO4C1)
- subfamily 5 (SLCO5A1)
- subfamily 6 (SLCO6A1)
(22) organic cation/anion/zwitterion transporter^[22]
- (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A18AS, SLC22A19, SLC22A20, SLC22A23, SLC22A24, SLC22A25, SLC22A31)
(23) Na+-dependent ascorbic acid transporter^[23]
- (SLC23A1, SLC23A2, SLC23A3, SLC23A4)
(24) Na+/(Ca2+-K+) exchanger^[24]
- (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6)
(25) mitochondrial carrier^[25]
- (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLC25A7, SLC25A8, SLC25A9, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46)
(26) multifunctional anion exchanger^[26]
- (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11)
(27) بروتين ناقل^[27]
- (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6)
(28) Na+-coupled nucleoside transport^[28]
- (SLC28A1, SLC28A2, SLC28A3)
(29) facilitative nucleoside transporter^[29]
- (SLC29A1, SLC29A2, SLC29A3, ناقل الغشاء البلازمي أحادي الأمين)
(30) zinc efflux^[30]
- (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)
(31) نحاس transporter^[31]
- (SLC31A1, SLC31A2)
(32) vesicular inhibitory amino acid transporter^[32]
- (SLC32A1)
(33) أسيتيل مرافق الإنزيم-أ transporter^[33]
- (SLC33A1)
(34) type II Na+-phosphate cotransporter^[34]
- (SLC34A1, SLC34A2, SLC34A3)
(35) nucleoside-sugar transporter^[35]
- subfamily A (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5)
- subfamily B (SLC35B1, SLC35B2, SLC35B3, SLC35B4)
- subfamily C (SLC35C1, SLC35C2)
- subfamily D (SLC35D1, SLC35D2, SLC35D3)
- subfamily E (SLC35E1, SLC35E2, SLC35E3, SLC35E4)
- subfamily F (SLC35F1, SLC35F2, SLC35F3, SLC35F4, SLC35F5)
- subfamily G (SLC35G1, SLC35G3, SLC35G4, SLC35G5, SLC35G6)
(36) proton-coupled amino acid transporter^[36]
- (SLC36A1, SLC36A2, SLC36A3, SLC36A4)
(37) sugar-phosphate/phosphate exchanger^[37]
- (SLC37A1, SLC37A2, SLC37A3, SLC37A4)
(38) System A & N, sodium-coupled neutral amino acid transporter^[38]
- (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A7, SLC38A8, SLC38A9, SLC38A10, SLC38A11)
(39) metal ion transporter^[39]
- (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14)
(40) basolateral iron transporter^[40]
- (SLC40A1)
(41) MgtE-like magnesium transporter
- (SLC41A1, SLC41A2, SLC41A3)
(42) Ammonia transporter^[41]^[42]
- (RHAG, RHBG, RHCG)
(43) Na+-independent, system-L like amino acid transporter
- (SLC43A1, SLC43A2, SLC43A3)
(44) Choline-like transporter
- (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5)
(45) Putative sugar transporter
- (SLC45A1, SLC45A2, SLC45A3, SLC45A4)
(46) Folate transporter
- (SLC46A1, SLC46A2, SLC46A3)
(47) multidrug and toxin extrusion
- (SLC47A1, SLC47A2)
(48) Heme transporter
(49) Transporters of the major facilitator superfamily
(50) Sugar efflux transporters of the SWEET family
(51) Transporters of steroid-derived molecules
(52) Riboflavin transporter family RFVT/SLC52

مصادر

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Koepsell H, Endou H (2004). "The SLC22 drug transporter family". Pflugers Arch. 447 (5): 666–676. doi:10.1007/s00424-003-1089-9. PMID 12883891.
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موسوعات ذات صلة :

موسوعة علم الأحياء الخلوي والجزيئي